Triethylamine → N-[2-(Diethylamino)ethyl]-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}urea

HRID 721546노트

반응식

HRID 721546 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[C:18]([CH3:23])[CH:17]=1.C(N(CC)CC)C.ClC(Cl)(O[C:35](=[O:41])OC(Cl)(Cl)Cl)Cl.[CH2:43]([N:45]([CH2:49][CH3:50])[CH2:46][CH2:47][NH2:48])[CH3:44]>C(Cl)(Cl)Cl.O>[CH2:43]([N:45]([CH2:49][CH3:50])[CH2:46][CH2:47][NH:48][C:35]([NH:20][C:19]1[CH:21]=[CH:22][C:16]([O:15][C:6]2[C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:9]=[CH:8][CH:7]=2)=[CH:17][C:18]=1[CH3:23])=[O:41])[CH3:44]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 60993N,N-DiethylethylenediamineHCID 94429TriphosgeneHCID 218905104-((6,7-Dimethoxyquinolin-4-yl)oxy)-2-methylaniline

생성물 1

HCID 21891105N-[2-(Diethylamino)ethyl]-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}urea수율 34%

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매2회

실험 절차

4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylaniline (100 mg) was dissolved in chloroform (10 ml) and triethylamine (1 ml) to prepare a solution. A solution of triphosgene (142 mg) in chloroform was then added to the solution, and the mixture was stirred at room temperature for 10 min. Next, N1,N1-diethyl-1,2-ethanediamine (56 mg) was added thereto, and the mixture was further stirred at room temperature for one hr. Water was added to stop the reaction, and the reaction solution was then extracted with chloroform, followed by concentration. The residue was purified on a column using chloroform/methanol to give the title compound (49 mg, yield 34%).

후처리

  1. stirringthe mixture was further stirred at room temperature for one hr
  2. customthe reaction
  3. extractionthe reaction solution was then extracted with chloroform
  4. concentrationfollowed by concentration
  5. customThe residue was purified on a column

출처 및 근거

ORD 기록
ord-2c970ec95d0e4e819b0441e67d90c143
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135466B2

반응 노트

불러오는 중…