Triethylamine → N-[2-(Dibutylamino)ethyl]-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

HRID 721579

반응식

HRID 721579 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1.C(N(CC)CC)C.ClC(Cl)(O[C:34](=[O:40])OC(Cl)(Cl)Cl)Cl.[CH2:42]([N:46]([CH2:50][CH2:51][CH2:52][CH3:53])[CH2:47][CH2:48][NH2:49])[CH2:43][CH2:44][CH3:45]>C(Cl)(Cl)Cl.O>[CH2:42]([N:46]([CH2:50][CH2:51][CH2:52][CH3:53])[CH2:47][CH2:48][NH:49][C:34]([NH:20][C:19]1[CH:21]=[CH:22][C:16]([O:15][C:6]2[C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:9]=[CH:8][CH:7]=2)=[CH:17][CH:18]=1)=[O:40])[CH2:43][CH2:44][CH3:45]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 77062N,N-DibutylethylenediamineHCID 94429TriphosgeneHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline

생성물 1

HCID 21890803N-[2-(Dibutylamino)ethyl]-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea수율 43.1%

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매2회

실험 절차

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (100 mg) was dissolved in chloroform (10 ml) and triethylamine (1 ml) to prepare a solution. A solution of triphosgene (151 mg) in chloroform was then added to the solution, and the mixture was stirred at room temperature for 10 min. Next, N1,N1-dibutyl-1,2-ethanediamine (88 mg) was added thereto, and the mixture was further stirred at room temperature for one hr. Water was added to stop the reaction, and the reaction solution was then extracted with chloroform, followed by concentration. The residue was purified on a column using chloroform/methanol to give the title compound (72 mg, yield 43%).

후처리

  1. stirringthe mixture was further stirred at room temperature for one hr
  2. customthe reaction
  3. extractionthe reaction solution was then extracted with chloroform
  4. concentrationfollowed by concentration
  5. customThe residue was purified on a column

출처 및 근거

ORD 기록
ord-bfee4618b2194ed7ace30b129b2ecf10
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135466B2

연결된 노트

불러오는 중…