Methyl iodide → Methyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate

HRID 722016

반응식

HRID 722016 반응식
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]([O:13][CH3:14])=[O:12])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.CI.[CH:17]([N-]C(C)C)(C)C.[Li+]>>[CH3:17][C:8]1([C:11]([O:13][CH3:14])=[O:12])[CH2:9][CH2:10][C:5]2([O:4][CH2:3][CH2:2][O:1]2)[CH2:6][CH2:7]1

참가 물질

4

반응물 3

HCID 6328Methyl iodideHCID 2724682Lithium diisopropylamideHCID 10845708Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

생성물 1

HCID 22591390Methyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate

실험 절차

According to the process described in the literature (JP83-118577), methyl 1,4-dioxaspiro [4.5]decan-8-carboxylate was reacted with methyl iodide in the presence of LDA (lithium diisopropylamide) to obtain methyl 8-methyl-1,4-dioxaspiro [4.5]decan-8-carboxylate (the compound (1) of the above figure).

출처 및 근거

ORD 기록
ord-afc59317940e481da20834cadb4f253c
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138397B2

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