Acetic Anhydride → 2-Pyridinemethanol, 2-acetate

HRID 722084

반응식

HRID 722084 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[O-].[C:9]([O:12]C(=O)C)(=[O:11])[CH3:10]>CCOC(C)=O>[C:9]([O:12][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1)(=[O:11])[CH3:10]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 136022-Methylpyridine 1-oxide

생성물 1

HCID 138812-Pyridinemethanol, 2-acetate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of the 2-methyl pyridine N-oxide (1.0 mmol) in acetic anhydride (5 mmol) was heated to reflux for 0.5 h. Work-up (EtOAc), drying (MgSO4), evaporation and purification by preparative TLC or flash chromatography afforded the 2-(acetoxymethyl)pyridine.

후처리

  1. temperatureto reflux for 0.5 h
  2. customdrying
  3. custom(MgSO4), evaporation and purification by preparative TLC or flash chromatography

출처 및 근거

ORD 기록
ord-46b932fbdc8540ac87584522c6800eb6
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138401B2

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