HCID 86591374, 화합물 → HCID 21882818, 화합물

HRID 722138노트

반응식

HRID 722138 반응식
[F:1][C:2]1[C:3]2[CH2:4][CH:5]3[C:14](=[N:15]O)[CH:8]([CH2:9][C:10]=2[CH:11]=[CH:12][CH:13]=1)[CH2:7][CH2:6]3>CC(O)=O.[OH-].[Na+].[Pt](=O)=O>[F:1][C:2]1[C:3]2[CH2:4][CH:5]3[CH:14]([NH2:15])[CH:8]([CH2:9][C:10]=2[CH:11]=[CH:12][CH:13]=1)[CH2:7][CH2:6]3

참가 물질

5

반응물 1

HCID 86591374HCID 86591374, 화합물

생성물 1

HCID 21882818HCID 21882818, 화합물수율 95.1%

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 176Acetic Acid용매HCID 14798Sodium Hydroxide용매

실험 절차

The oxime from Step 3 (590 mg, 2.69 mmol) and platinum dioxide (40 mg) in AcOH (20 ml) were hydrogenated in a Parr reactor at 30 psi for 2 hours. The mixture was filtered through Celite and the filtrate was concentrated by lyophilization to give an off-white solid. The solid was dispersed in 1N NaOH and extracted with DCM. The organic extract was dried and concentrated to dryness to give a yellow oil 525 mg (95%). m/z 206 (M+H+).

후처리

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated by lyophilization
  3. customto give an off-white solid
  4. extractionextracted with DCM
  5. extractionThe organic extract
  6. customwas dried
  7. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-f105cd18c83d4c0a84a55a9258d0b196
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138400B2

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