반응식
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([S:21][CH3:22])=[C:8]([S:10]([C:13]2[CH:14]=[N:15][C:16](Cl)=[C:17]([Br:19])[CH:18]=2)(=[O:12])=[O:11])[CH:9]=1)=[O:4].[N:23]1[CH:27]=[C:26]([CH2:28][CH2:29][NH2:30])[NH:25][CH:24]=1.C(N(C(C)C)CC)(C)C.C1COCC1>CO.C(Cl)Cl.CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([S:21][CH3:22])=[C:8]([S:10]([C:13]2[CH:14]=[N:15][C:16]([NH:30][CH2:29][CH2:28][C:26]3[NH:25][CH:24]=[N:23][CH:27]=3)=[C:17]([Br:19])[CH:18]=2)(=[O:12])=[O:11])[CH:9]=1)=[O:4]참가 물질
7
반응물 4
생성물 1
시약·촉매·용매 2
실험 절차
The reaction was conducted following the procedure for Example 156: step a, using. 4-(5-bromo-6-chloro-pyridine-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester (0.050 g, 0.113 mmol), (Example 2: step c), 2-(3H-imidazol-4-yl)-ethylamine (0.027 g, 0.146 mmol), diisopropylethylamine (0.073 g, 0.565 mmol), THF [0.5 mL], DMF [0.5 mL]. Chromatography of the residue (0%–6% MeOH/DCM) yielded the title compound. ESI-MS (m/z): Calcd. for C17H17BrN4O4S3: 518.44 (M+H); found 517.0, 519.
출처 및 근거
- ORD 기록
- ord-7ab971d9d07543b9a439f98aa13fc6d2
- 출처 데이터셋
- uspto-grants-2006_11
- 특허 번호
- US07138530B2
연결된 노트
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