Methyl propionate → 3-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester

HRID 72316

반응식

HRID 72316 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2OC(=O)[S:17][N:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]([O:25][CH3:26])(=[O:24])[CH2:22][CH3:23]>ClC1C=CC=CC=1>[CH3:26][O:25][C:21]([C:22]1[S:17][N:16]=[C:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:14][CH:13]=2)[CH:23]=1)=[O:24]

참가 물질

4

반응물 2

HCID 11124Methyl propionateHCID 595495255-(4-Benzyloxyphenyl)-[1,3,4]oxathiazol-2-one

생성물 1

HCID 666177513-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

5-(4-benzyloxy-phenyl)-[1,3,4]oxathiazol-2-one (0.4 g, 1.4 mmol) and 0.23 ml of methyl propionate were dissolved in 10 ml of chlorobenzene and then refluxed overnight. The solvent was distilled off under reduced pressure and the obtained crude compound was purified by silica gel column chromatography to obtain 3-(4-benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester as a desired compound.

후처리

  1. temperaturerefluxed overnight
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained crude compound
  4. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-bae299a0dd6140dd87b26a0cdc892800
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828992B2

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