Hydrochloric Acid → N-(3-trifluoromethyl-phenyl)-4-(2-carboxy-4-pyridyl)-2-pyrimidineamine

HRID 724820노트

반응식

[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][N:19]=C(C#N)[CH:17]=3)[CH:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1.[OH-:26].[Na+].Cl.[CH2:29]([OH:31])[CH3:30]>>[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][N:19]=[C:30]([C:29]([OH:26])=[O:31])[CH:17]=3)[CH:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 14798Sodium Hydroxide

HCID 19711150N-(3-trifluoromethyl-phenyl)-4-(2-cyano-4-pyridyl)-2-pyrimidineamine

생성물 1

HCID 19711155N-(3-trifluoromethyl-phenyl)-4-(2-carboxy-4-pyridyl)-2-pyrimidineamine

실험 절차

100 mg (0.293 mmol) of N-(3-trifluoromethyl-phenyl)-4-(2-cyano4-pyridyl)-2-pyrimidineamine are stirred in 15 ml of ethanol and 15 ml of 2N sodium hydroxide solution for 3 hours at 60°. After acidifying with 4N hydrochloric acid, N-(3-trifluoromethyl-phenyl)-4-(2-carboxy-4-pyridyl)-2-pyrimidineamine is obtained; m.p. 241°-245°, FAB-MS: 361 (M+ +H).

출처 및 근거

ORD 기록: ord-feff76e2458642cb8ca1ea7b01af1cb7
출처 데이터셋: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05705502

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