Water → β-AMinoMethyl-benzeneethanol

HRID 727942

반응식

HRID 727942 반응식
[NH2:1][CH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:4]C(O)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH2:20].[OH-].[Na+]>C(COC)OC>[NH2:1][CH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:4][OH:20]

참가 물질

6

반응물 4

HCID 962WaterHCID 14113PhenibutHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydride

생성물 1

HCID 11286566β-AMinoMethyl-benzeneethanol

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

For the preparation of the alcohols VI used in Examples (3a) and (3b). 10 g of 3-amino-2-phenylpropanecarboxylic acid in 150 ml of monoglyme were stirred with 3 g of LiAlH4 for 20 hrs. Then, 12 ml of water and 3 ml of 10% sodium hydroxide solution were slowly added thereto. The mixture was filtered and the filtrate was again evaporated with toluene. There was obtained 8.4 g of β-(aminomethyl)-phenethyl alcohol.

후처리

  1. filtrationThe mixture was filtered
  2. customthe filtrate was again evaporated with toluene

출처 및 근거

ORD 기록
ord-94cfd474d910450e9c00447414ac647c
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05045567

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