Hydrochloric Acid → 4-Fluoro-alpha-(4-fluorophenyl)benzenemethanamine

HRID 730430노트

반응식

HRID 730430 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:16]C=O)[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.Cl.[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[NH2:16])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 25126459N-[Bis(4-fluorophenyl)methyl]formamide

생성물 1

HCID 109550394-Fluoro-alpha-(4-fluorophenyl)benzenemethanamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixed solution of bis(4-fluorophenyl)methylformamide (13.9 g, 56.2 mmol), concentrated hydrochloric acid (80 ml) and methanol (160 ml) was stirred at 90° C. for 1.5 hours and cooled to room temperature, then a 6 N aqueous sodium hydroxide solution (170 ml) was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the objective product as a solid material. Yield (amount) 11.5 g, yield (rate) 93.5%

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-7f54a19e89a546a899f2de2e0d9bdedf
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582651B2

반응 노트

불러오는 중…