홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Hydroxide → 5-Formyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid (3-diethylamino-2-hydroxy-propyl)-amide

HRID 731161
노트
인쇄 미리보기

반응식

HRID 731161 반응식
[CH:1]([C:3]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([OH:11])=O)[C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:2].[NH2:18][CH2:19][CH:20]([OH:27])[CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24].C1C=CC2N(O)N=NC=2C=1.C(=O)(O)[O-].[Na+].[OH-].[Na+]>C(Cl)(Cl)Cl>[CH2:23]([N:22]([CH2:25][CH3:26])[CH2:21][CH:20]([OH:27])[CH2:19][NH:18][C:9]([C:5]1[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:3]([CH:1]=[O:2])[NH:7][C:6]=1[CH3:8])=[O:11])[CH3:24]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 14798Sodium HydroxideHCID 757711-HydroxybenzotriazoleHCID 977491-Amino-3-(diethylamino)propan-2-olHCID 516892Sodium BicarbonateHCID 219156195-Formyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylic Acid

생성물 1

HCID 206047855-Formyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid (3-diethylamino-2-hydroxy-propyl)-amide
수율 25.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 5-Formyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid (1.0 gm, 4.36 mmol), 1-amino-3-diethylamino-2-propanol (950 mg, 6.54 mmol), DDC (900 mg, 4.36 mmol) and HOBt (884 mg, 6.54 mmol) in chloroform (60 mL) was stirred at rt for 12 hrs. The reaction was poured into sat. Sodium bicarbonate (60 mL) and to it was added 1N NaOH (8 mL). It was then extracted with EtOAc (3×100 mL), washed with water and brine, dried and concentrated to give 400 mg of 5-Formyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid (3-diethylamino-2-hydroxy-propyl)-amide.

후처리

  1. extractionIt was then extracted with EtOAc (3×100 mL)
  2. washwashed with water and brine
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-85a71b16d5164905a63969f0e8698d41
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07582756B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트