Ammonium Acetate → 3-[(3-fluoro-6-methylphenanthridin-5(6H)-yl)carbonyl]phenol

HRID 731985

반응식

HRID 731985 반응식
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]([NH2:17])[CH3:16].FC1C=C(F)C=CC=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:32](=[O:34])C.C([O-])(=[O:37])C.[NH4+].C([BH3-])#N.[Na+]>CO>[F:8][C:6]1[CH:7]=[CH:2][C:3]2[C:9]3[C:10]([CH:15]([CH3:16])[N:17]([C:32]([C:27]4[CH:28]=[C:29]([OH:37])[CH:30]=[CH:31][CH:26]=4)=[O:34])[C:4]=2[CH:5]=1)=[CH:11][CH:12]=[CH:13][CH:14]=3

참가 물질

6

반응물 4

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224822721-(2',4'-Difluoro-1,1'-biphenyl-2-yl)ethanoneHCID 224823761-[2-(2,4-Difluorophenyl)phenyl]ethan-1-amine

생성물 1

HCID 115009123-[(3-fluoro-6-methylphenanthridin-5(6H)-yl)carbonyl]phenol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-(-2′,4′-difluoro-biphenyl-2-yl)-ethylamine—The title compound was prepared from 1-(2′,4′-difluoro-1,1′-biphenyl-2-yl)ethanone (3.67 g, 15.8 mmol), anhydrous methanol (200 mL), ammonium acetate (12.2 g, 158 mmol), and sodium cyanoborohydride (1.99 g, 31.6 mmol) according to the procedure and in the same manner as described in Example 24, step b resulting in the isolation of a clear oil that was used without further purification. MS [(ES+), m/z]: 217 [M-16]+, benzylic cation as a result of the loss of NH2.

후처리

  1. customresulting in the isolation of a clear oil that
  2. customwas used without further purification
  3. customMS [(ES+), m/z]: 217 [M-16]+, benzylic cation as a result of the loss of NH2

출처 및 근거

ORD 기록
ord-1b36fa801b1d4d6c9ac0302aa85ce949
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585871B2

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