Hydrochloric Acid → (S)-2-sec-Butylamino-6-cyano-isonicotinic acid
반응식
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]#[N:11])[N:7]=[C:6]([NH:12][C@H:13]([CH2:15][CH3:16])[CH3:14])[CH:5]=1.[OH-].[Na+].Cl>CO>[C@@H:13]([NH:12][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([C:10]#[N:11])[N:7]=1)[C:3]([OH:17])=[O:2])([CH2:15][CH3:16])[CH3:14]참가 물질
5
실험 절차
Dissolve (S)-2-sec-butylamino-6-cyano-isonicotinic acid methyl ester (250 mg, 0.93 mmol) in methanol (3 mL). Slowly add 2 N NaOH (1.5 mL) and stir overnight at room temperature. Acidify to about pH=6 with 5 N HCl and concentrate. Dilute with ethyl acetate (20 mL) and wash the organic layer with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound.
후처리
- concentrationconcentrate
- additionDilute with ethyl acetate (20 mL)
- washwash the organic layer with saturated aqueous sodium chloride
- dry with materialdry (magnesium sulfate)
- concentrationconcentrate
출처 및 근거
- ORD 기록
- ord-9d18502c30cb44ef82df76a491976745
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07585885B2
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