Chloroacetic Acid → HCID 68814711, 화합물

HRID 732510

반응식

HRID 732510 반응식
S([O-])([O-])=S.[Na+].[Na+].[C:7](=O)(O)[O-].[Na+].[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([S:23](Cl)(=[O:25])=[O:24])[C:21]=1[F:22])[C:16]([OH:18])=[O:17].ClCC(O)=O.[OH-].[Na+]>O>[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([S:23]([CH3:7])(=[O:25])=[O:24])[C:21]=1[F:22])[C:16]([OH:18])=[O:17]

참가 물질

7

반응물 5

HCID 300Chloroacetic AcidHCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 15847209sodium thiosulfite anhydrousHCID 509984803-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid

생성물 1

HCID 68814711HCID 68814711, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To sodium thiosulfite (2.6 g, 20.7 mmol) and sodium bicarbonate (1.74 g, 20.7 mmol) in water (20 mL) at 75° C. add 3-bromo-5-chlorosulfonyl-4-fluorobenzoic acid (6.25 g, 19.7 mmol) in portions over 5 min. After 1 h, cool to room temperature and add chloroacetic acid (5.29 g, 56 mmol) and NaOH (1.18 g, 29.5 mmol) and reflux 16 h. Cool to room temperature and collect the title compound as a solid

후처리

  1. temperaturereflux 16 h
  2. temperatureCool to room temperature
  3. customcollect the title compound as a solid

출처 및 근거

ORD 기록
ord-47919f6767db4f28a9986e82414d5468
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585885B2

연결된 노트

불러오는 중…