Hydrochloric Acid → HCID 68814780, 화합물

HRID 732561노트

반응식

HRID 732561 반응식
C[O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15](C(=O)C(C)C)[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1.[OH-:23].[Na+].Cl>CO>[C:3]([C:5]1[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])=[CH:14][CH:15]=[CH:16][C:4]=1[C:3]([OH:2])=[O:22])(=[O:23])[CH:4]([CH3:16])[CH3:5]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68814779HCID 68814779, 화합물

생성물 1

HCID 68814780HCID 68814780, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Dissolve 5-isobutyryl-N-methyl-N-propyl-isophthalamic acid methyl ester (50 mg, 0.16 mmol) in methanol (3 mL) and add dropwise 2 N NaOH (0.16 mL). Stir the mixture at room temperature for 6 h, store overnight at 4° C. and acidify to about pH=6 by 5 N HCl. Concentrate to near dryness and dilute the residue with ethyl acetate. Wash with saturated aqueous sodium chloride solution and extract the organic layer, dry (magnesium sulfate) and concentrate to give the title compound.

후처리

  1. waitstore overnight at 4° C.
  2. concentrationConcentrate
  3. additiondilute the residue with ethyl acetate
  4. washWash with saturated aqueous sodium chloride solution
  5. extractionextract the organic layer
  6. dry with materialdry (magnesium sulfate)
  7. concentrationconcentrate

출처 및 근거

ORD 기록
ord-2eb32b244a384d9fb7c9d3798f9a92d3
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585885B2

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