1-Butanol → 4-Bromo-1-butoxy-2-fluorobenzene
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([F:9])[CH:3]=1.[CH2:10](O)[CH2:11][CH2:12][CH3:13].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OC(C)C)=O)=NC(OC(C)C)=O>O1CCCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][CH2:12][CH3:13])=[C:4]([F:9])[CH:3]=1참가 물질
6
실험 절차
0.315 mol of each of 4-bromo-2-fluorophenol (1), 1-butanol and triphenylphosphine were dissolved in 1000 ml of tetrahydrofuran, and 0.315 mol of diisopropyl azodicarboxylate was added dropwise at about 20° C. After the mixture had been stirred overnight, the solvent was removed by distillation in a rotary evaporator, and the residue was subjected to conventional work-up, giving the compound (2) in a yield of 95.6% of theory.
후처리
- customthe solvent was removed by distillation in a rotary evaporator
출처 및 근거
- ORD 기록
- ord-d7098213ef994e7f871969c33d7d6733
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087272B2
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