Hydrazine hydrate (1:1) → HCID 178489137, 화합물

HRID 735424노트

반응식

HRID 735424 반응식
[Cl:1][C:2]1[C:3](F)=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=O)[CH:5]=[CH:6][CH:7]=1.O.[NH2:20][NH2:21]>CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:21][N:20]=[C:8]2[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 11471075(3-Chloro-2-fluorophenyl)-(4-methoxyphenyl)-methanone

생성물 1

HCID 178489137HCID 178489137, 화합물수율 90.6%

시약·촉매·용매 1

HCID 142844-(Dimethylamino)pyridine촉매

실험 절차

Prepared as in Example 104 from (3-chloro-2-fluoro-phenyl)-(4-methoxy-phenyl)-methanone (0.84 g, 3.2 mmol), hydrazine hydrate (1.0 mL, 32 mmol) and DMAP (0.39 g, 3.2 mmol) to give the product (0.75 g) as a white solid.

출처 및 근거

ORD 기록
ord-8e3576215c0b4dd98d39fcd1a85857dd
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592363B2

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