Hydrazine hydrate (1:1) → HCID 178489142, 화합물

HRID 735425노트

반응식

HRID 735425 반응식
F[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)=O.O.[NH2:20][NH2:21]>CN(C1C=CN=CC=1)C>[F:8][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:2]=1[NH:21][N:20]=[C:9]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 62650974(2,3-Difluorophenyl)(4-methoxyphenyl)methanone

생성물 1

HCID 178489142HCID 178489142, 화합물수율 79.7%

시약·촉매·용매 1

HCID 142844-(Dimethylamino)pyridine촉매

실험 절차

Prepared as in Example 104 from (2,3-difluorophenyl)-(4-methoxy-phenyl)-methanone (1.1 g, 4.4 mmol), hydrazine hydrate (1.37 mL, 44 mmol) and DMAP (0.54 g, 4.4 mmol) to give the product (0.85 g) as a white solid.

출처 및 근거

ORD 기록
ord-213803fdd9704bfc9534d29da1eaee7a
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592363B2

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