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Hydrochloric Acid → 2-(2,4-Dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylic acid

HRID 735440
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인쇄 미리보기

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HRID 735440 반응식
[CH3:1][C:2]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:3]=1[CH2:4][N:5]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[C:12]2[C:7]([C:8]([C:21]([O:23]C)=[O:22])=[CH:9][CH:10]=[CH:11]2)=[N:6]1.[OH-].[Na+].Cl>CO>[CH3:1][C:2]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:3]=1[CH2:4][N:5]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[C:12]2[C:7]([C:8]([C:21]([OH:23])=[O:22])=[CH:9][CH:10]=[CH:11]2)=[N:6]1
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11696743methyl 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylate

생성물 1

HCID 670212802-(2,4-Dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylic acid수율 0.5%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

A solution of methyl 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylate (0.195 g, 0.5 mmol) in 5 mL methanol was treated with 1 mL of 1N NaOH and stirred at 50° C. for 1 hour. The solution was neutralized with dilute HCl and partitioned with ethyl acetate and H2O. The organic phase was dried (Na2SO4) and concentrated in vacuo to give 0.95 mg of the title compound as a yellow solid.

후처리

  1. custompartitioned with ethyl acetate and H2O
  2. dry with materialThe organic phase was dried (Na2SO4)
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-78731feab545482c901a9ad2c7579301
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07592363B2

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