1-Chloro-4-(trifluoromethyl)benzene → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

HRID 737350

반응식

HRID 737350 반응식
Cc1ccc(N)cc1.FC(F)(F)c1ccc(Cl)cc1>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c(C(C)C)c1.CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CCOC(=O)c1cc(C)on1.CS(C)=O>Cc1ccc(Nc2ccc(C(F)(F)F)cc2)cc1

참가 물질

7

반응물 2

HCID 73941-Chloro-4-(trifluoromethyl)benzeneHCID 7813p-Toluidine

생성물 1

HCID 187127994-methyl-N-(4-(trifluoromethyl)phenyl)aniline수율 22.166%

시약·촉매·용매 4

HCID 76677Ethyl 5-methylisoxazole-3-carboxylate시약HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramine시약HCID 178439018HCID 178439018, 화합물촉매HCID 679Dimethyl Sulfoxide용매5회

반응 조건

온도
60 °C

실험 절차

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

후처리

  1. addition기록된 절차가 없습니다

출처 및 근거

ORD 기록
ord-15078f42d6c545dbae57e7831a14f5dd
출처 데이터셋
Ahneman

연결된 노트

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