2,5 Dibromotoluene → 1,4-Dibromo-2-(bromomethyl)benzene

HRID 742475

반응식

HRID 742475 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH3:9].C1C(=O)N([Br:17])C(=O)C1>C(Cl)(Cl)(Cl)Cl.C(OOCC1C=CC=CC=1)C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][Br:17]

참가 물질

5

반응물 2

HCID 120062,5 DibromotolueneHCID 67184N-bromobutanimide

생성물 1

HCID 53260381,4-Dibromo-2-(bromomethyl)benzene수율 55.7%

시약·촉매·용매 2

HCID 11229634Benzyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 75 g (0.3 mol) of 2,5-dibromotoluene in 1 L of carbon tetrachloride was added 58.73 g (0.33 mol) of NBS and 50 mg of benzyl peroxide, and the resulting mixture was refluxed with stirring for 24 h. The mixture was cooled, and concentrated in vacuo. The residue was crystallized from hot methanol and washed with hexane to afford 54.5 g (55.7%) of 2.5-dibromobenzyl bromide as a solid.

후처리

  1. temperaturethe resulting mixture was refluxed
  2. temperatureThe mixture was cooled
  3. concentrationconcentrated in vacuo
  4. customThe residue was crystallized from hot methanol
  5. washwashed with hexane

출처 및 근거

ORD 기록
ord-d1e95f67272f45da9c565ac04bac9e84
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05554620

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