Water → 4-Cyanophenyl 4-[(prop-2-en-1-yl)oxy]benzoate

HRID 742522노트

반응식

HRID 742522 반응식
[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)[CH:2]=[CH2:3].[C:14]([C:16]1[CH:21]=[CH:20][C:19](O)=[CH:18][CH:17]=1)#[N:15].O>C(Cl)(Cl)Cl>[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([O:11][C:19]2[CH:20]=[CH:21][C:16]([C:14]#[N:15])=[CH:17][CH:18]=2)=[O:10])=[CH:7][CH:6]=1)[CH:2]=[CH2:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 130194-CyanophenolHCID 4606904-(Prop-2-en-1-yloxy)benzoic acid

생성물 1

HCID 149851184-Cyanophenyl 4-[(prop-2-en-1-yl)oxy]benzoate수율 77.1%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

15.0 g of PPE, 4.00 g (22.4 mmol) of the compound (12) and 2.66 g (22.3 mmol) of p-cyanophenol were dissolved in ml of chloroform under an argon gas atmosphere and the whole was stirred at room temperature overnight. After addition of water to the reaction mixture, the whole was extracted with methylene chloride. After removal of the solvent by distillation, the residue was purified by silica gel column chromatography to obtain 4.80 g of p-cyanophenyl p-allyloxybenzoate (17) as a white solid (yield: 76.7%).

후처리

  1. extractionthe whole was extracted with methylene chloride
  2. customAfter removal of the solvent
  3. distillationby distillation
  4. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-619c789cc3b64082989a30e7db5218b9
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05554706

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