Water → cis-3-(3-(3-Hexenyloxy)-1,2,5-thiadiazol-4-yl)pyridine

HRID 744639

반응식

HRID 744639 반응식
[CH2:1]([OH:7])[CH2:2]/[CH:3]=[CH:4]\[CH2:5][CH3:6].[H-].[Na+].Cl[C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1.O>O1CCCC1>[CH2:1]([O:7][C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1)[CH2:2]/[CH:3]=[CH:4]\[CH2:5][CH3:6]

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 52811673-HexenolHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

생성물 1

HCID 70144893cis-3-(3-(3-Hexenyloxy)-1,2,5-thiadiazol-4-yl)pyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of cis-3-hexen-1-ol (900 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl) pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

후처리

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether phase was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-12110238c5294e78ae8381494095e1e8
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05559138

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