Diisopropylethylamine → (6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone
반응식
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](Cl)=[O:9])[CH:3]=1.CCN(C(C)C)C(C)C.[NH:20]1[CH:28]2[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]2)[CH2:22][CH2:21]1>ClCCl>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([N:20]2[CH:28]3[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[CH2:22][CH2:21]2)=[O:9])[CH:3]=1참가 물질
5
실험 절차
0.517 g (2.92 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 10 mL dichloromethane were combined with 1.07 mL (6.00 mmol) DIPEA. 0.73 g (2.92 mmol) octahydroindole in 10 mL DCM was slowly added dropwise. After 2 h stirring at RT the mixture was diluted with dichloromethane and extracted with water. The organic phase was separated off, dried on sodium sulphate, filtered, evaporated down i. vac. and dried.
후처리
- extractionextracted with water
- customThe organic phase was separated off
- customdried on sodium sulphate
- filtrationfiltered
- customevaporated down i
- customand dried
출처 및 근거
- ORD 기록
- ord-d9e6d1a79cb5434b9b413788f1e27a35
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08829006B2
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