Diisopropylethylamine → (6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone

HRID 74510

반응식

HRID 74510 반응식
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](Cl)=[O:9])[CH:3]=1.CCN(C(C)C)C(C)C.[NH:20]1[CH:28]2[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]2)[CH2:22][CH2:21]1>ClCCl>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([N:20]2[CH:28]3[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[CH2:22][CH2:21]2)=[O:9])[CH:3]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 107275Octahydro-1H-indoleHCID 184220986-Chloropyrimidine-4-carbonyl chloride

생성물 1

HCID 58386728(6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

0.517 g (2.92 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 10 mL dichloromethane were combined with 1.07 mL (6.00 mmol) DIPEA. 0.73 g (2.92 mmol) octahydroindole in 10 mL DCM was slowly added dropwise. After 2 h stirring at RT the mixture was diluted with dichloromethane and extracted with water. The organic phase was separated off, dried on sodium sulphate, filtered, evaporated down i. vac. and dried.

후처리

  1. extractionextracted with water
  2. customThe organic phase was separated off
  3. customdried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down i
  6. customand dried

출처 및 근거

ORD 기록
ord-d9e6d1a79cb5434b9b413788f1e27a35
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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