Hydrochloric Acid → 2,4-Dibromo-beta-butylbenzeneethanol

HRID 745276노트

반응식

HRID 745276 반응식
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH2:14][CH2:15][CH2:16][CH3:17])[C:10](OC)=[O:11].O.O.[I-].[Li+].[BH4-].[Na+].Cl>C(#N)C>[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:10][OH:11]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 12343320Methyl 2,4-dibromo-alpha-butylbenzeneacetateHCID 23688289Lithium iodide (LiI), dihydrate

생성물 1

HCID 123433642,4-Dibromo-beta-butylbenzeneethanol수율 100%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 16.5 parts of methyl 2,4-dibromo-α-butylbenzeneacetate, 11.5 parts of lithium iodide dihydrate and 180 parts of acetonitrile is stirred till all solid enters solution. Then there are added portionwise 3.6 parts of sodium borohydride. Upon completion, the whole is heated to reflux and stirring is continued overnight at reflux temperature. After cooling, the reaction mixture is acidified with a diluted hydrochloric acid solution and poured onto water. The product is extracted with 2,2'-oxybispropane. The extract is washed with water, dried, filtered and evaporated, yielding 15 parts (100%) of 2,4-dibromo-β-butylbenzeneethanol as a residue.

후처리

  1. temperatureUpon completion, the whole is heated
  2. temperatureto reflux
  3. stirringstirring
  4. temperatureat reflux temperature
  5. temperatureAfter cooling
  6. additionpoured onto water
  7. extractionThe product is extracted with 2,2'-oxybispropane
  8. washThe extract is washed with water
  9. customdried
  10. filtrationfiltered
  11. customevaporated

출처 및 근거

ORD 기록
ord-99f51b1d1de5474dab62edc6037e9488
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04598085

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