Ammonium Acetate → 9-Methyl-9-azabicyclo(3.3.1)nonan-3-amine
반응식
[CH3:1][N:2]1[CH:7]2[CH2:8][CH2:9][CH2:10][CH:3]1[CH2:4][C:5](=[N:11]O)[CH2:6]2.C([O-])(=O)C.[NH4+]>C(O)C.[Ni]>[NH2:11][CH:5]1[CH2:4][CH:3]2[N:2]([CH3:1])[CH:7]([CH2:8][CH2:9][CH2:10]2)[CH2:6]1참가 물질
5
실험 절차
N-methyl-9-azabicyclo-[3.3.1]-nonan-3-one oxime (3.25 g., 0.02 mole) was dissolved in ethanol and hydrogenated over Raney nickel in the presence of ammonium acetate at 300 p.s.i. at 50° C. for 24 hours. The mixture was filtered, evaporated in vacuo, dissolved in dilute hydrochloric acid, basified and extracted into ethyl acetate. The combined organic layers were dried (K2CO3), filtered and evaporated in vacuo to yield 3-amino-9-methyl-9-azabicyclo-[3.3.1]-nonane (2.67 g., 90%), used without further purification.
후처리
- filtrationThe mixture was filtered
- customevaporated in vacuo
- dissolutiondissolved in dilute hydrochloric acid
- extractionextracted into ethyl acetate
- dry with materialThe combined organic layers were dried (K2CO3)
- filtrationfiltered
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-f1561701e6b24ec198473128bf3b15cf
- 출처 데이터셋
- uspto-grants-1986_07
- 특허 번호
- US04599420
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