Sodium Hydroxide → 6-fluoro-2,3-dihydro-1H-indole

HRID 74568

반응식

HRID 74568 반응식
C([BH3-])#N.[Na+].[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1.[OH-].[Na+]>C(O)(=O)C>[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][CH2:11][NH:12]2)=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 3512786-FluoroindoleHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 2604006-fluoro-2,3-dihydro-1H-indole

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Under a nitrogen atmosphere 0.29 g (4.6 mmol) sodium cyanoborohydride were added batchwise to 0.54 g (4.0 mmol) 6-fluoroindole in 5.0 mL glacial acetic acid and the mixture was stirred for 30 min. Then the reaction mixture was poured onto a 4N aqueous sodium hydroxide solution and extracted with EtOAc. The combined organic phases were washed several times with saturated sodium hydrogen carbonate solution, dried on sodium sulphate and evaporated down.

후처리

  1. extractionextracted with EtOAc
  2. washThe combined organic phases were washed several times with saturated sodium hydrogen carbonate solution
  3. customdried on sodium sulphate
  4. customevaporated down

출처 및 근거

ORD 기록
ord-5be21d4c530342cc93a44e37b2e1b052
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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