Potassium Carbonate → HCID 23312131, 화합물

HRID 745801

반응식

HRID 745801 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:12]=[C:13]([OH:19])[C:14]([OH:18])=[CH:15][C:16]=2[CH3:17])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH:27](Br)[C:28]([OH:30])=[O:29]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[C:16]([CH3:17])=[CH:15][C:14]3[O:18][CH:27]([C:28]([OH:30])=[O:29])[O:19][C:13]=3[CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 12433Dibromoacetic AcidHCID 23312109HCID 23312109, 화합물

생성물 1

HCID 23312131HCID 23312131, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

In a manner analogous to that described in Example 15, 60.0 g of 4-(4-bromophenylsulphonyl)-5-methyl-1,2-benzenediol are reacted in the presence of 120 g of potassium carbonate in 300 ml of dimethylformamide with a solution of 76.2 g of dibromoacetic acid in 100 ml of dimethylformamide. After working up and chromatographic purification in a manner analogous to that described in Example 15 and crystallisation from 1,2-dichloroethane, 5-(4-bromophenylsulphonyl)-6-methyl-1,3-benzodioxole-2-carboxylic acid is obtained in the form of sand-coloured crystals having a melting point of 170°-172.5°.

후처리

  1. customchromatographic purification in a manner analogous to
  2. customthat described in Example 15 and crystallisation from 1,2-dichloroethane

출처 및 근거

ORD 기록
ord-cbf23a6c952845489fcf099f6f664760
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04600709

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