Phthalic Anhydride → Fluorescein phthalamic acid

HRID 745849

반응식

HRID 745849 반응식
[CH:1]1[C:6]([NH2:7])=[CH:5][C:4]2[C:8]([O:10][C:11]3([C:21]4[CH:22]=[CH:23][C:24]([OH:26])=[CH:25][C:20]=4[O:19][C:13]4[CH:14]=[C:15]([OH:18])[CH:16]=[CH:17][C:12]3=4)[C:3]=2[CH:2]=1)=[O:9].[C:27]1(=[O:37])[O:32][C:30](=[O:31])[C:29]2=[CH:33][CH:34]=[CH:35][CH:36]=[C:28]12>C(O)(=O)C>[CH:1]1[CH:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[C:3]([C:11]2[C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=3[O:19][C:20]3[C:21]=2[CH:22]=[CH:23][C:24]([CH:25]=3)=[O:26])[CH:2]=1.[C:27]([OH:32])(=[O:37])[C:28]1[C:29](=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:30]([NH2:7])=[O:31]

참가 물질

4

반응물 2

HCID 6811Phthalic AnhydrideHCID 768455-Aminofluorescein

생성물 1

HCID 131714783Fluorescein phthalamic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 350 mg (0.001 mol) of 5-aminofluorescein and 200 mg of phthalic anhydride in 5 milliliters of glacial acetic acid was stirred at ambient temperature for 48 hours. The yellow reddish product was filtered and washed once with acetic acid and twice with diethyl ether. 460 Mg of fluorescein-phthalamic acid was obtained. I.R (KBR) showed bands at 3060; 3000; 1685; 1590; 1540; 1480; 1460; 1430; 1350; 1310; 1270; 1230; 1195; 1150; and 1115 cm-1.

후처리

  1. filtrationThe yellow reddish product was filtered
  2. washwashed once with acetic acid and twice with diethyl ether

출처 및 근거

ORD 기록
ord-7cbb0db406bd487cad6863495797162b
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04600775

연결된 노트

불러오는 중…