Mesitylene → 3-Allyl-5-ethoxy-4-hydroxybenzaldehyde

HRID 746331노트

반응식

HRID 746331 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12]CC=C)[CH:7]=[O:8])[CH3:2].[OH-].[Na+].[C:18]1(C)[CH:23]=C(C)C=C(C)[CH:19]=1>>[CH2:23]([C:10]1[CH:9]=[C:6]([CH:5]=[C:4]([O:3][CH2:1][CH3:2])[C:11]=1[OH:12])[CH:7]=[O:8])[CH:18]=[CH2:19]

참가 물질

4

반응물 3

HCID 7947MesityleneHCID 14798Sodium HydroxideHCID 35257364-(allyloxy)-3-ethoxybenzaldehyde

생성물 1

HCID 8813293-Allyl-5-ethoxy-4-hydroxybenzaldehyde

실험 절차

3-Ethoxy-4-(2-propenyloxy)benzaldehyde (20.0 g, 0.087 mol) was heated under reflux in 75 ml mesitylene (1,3,5-trimethylbenzene) for 20 hours. After cooling, 250 ml 2N sodium hydroxide were added to the reaction mixture. The aqueous phase was washed two times with diethyl ether. The aqueous phase was subsequently acidified with concentrated hydrochloric acid under ice cooling and then extracted with ethyl acetate. After drying and concentrating the organic phase, there remained a light orange-colored oil that crystallized on cooling.

후처리

  1. temperatureAfter cooling
  2. washThe aqueous phase was washed two times with diethyl ether
  3. extractionextracted with ethyl acetate
  4. customAfter drying
  5. concentrationconcentrating the organic phase, there
  6. customthat crystallized
  7. temperatureon cooling

출처 및 근거

ORD 기록
ord-9228b63a0d4f4087b9617c6b7a5a7776
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393367B2

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