Methyl iodide → 4-Bromo-2,6-difluoroanisole

HRID 746770

반응식

HRID 746770 반응식
IC.[Br:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([OH:11])=[C:6]([F:12])[CH:5]=1.[C:13](=O)([O-])[O-].[K+].[K+].ClCCl>CC(C)=O>[Br:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:13])=[C:6]([F:12])[CH:5]=1

참가 물질

6

반응물 4

HCID 6328Methyl iodideHCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 27362924-Bromo-2,6-difluorophenol

생성물 1

HCID 27732874-Bromo-2,6-difluoroanisole

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

Add iodomethane (2.0 ml, 32.1 mmol) dropwise to a suspension of 4-bromo-2,6-difluorophenol (5.90 g, 28.2 mmol) and potassium carbonate (4.40 g, 31.8 mmol) in acetone (50 ml) at room temperature while stirring vigorously. Heat the mixture under reflux overnight. Evaporate acetone and add dichloromethane. Filter through silica eluting the product with dichloromethane/EtOAc. Concentrate to yield the title compound.

후처리

  1. temperatureHeat the mixture
  2. temperatureunder reflux overnight
  3. filtrationFilter through silica eluting the product with dichloromethane/EtOAc
  4. concentrationConcentrate

출처 및 근거

ORD 기록
ord-a291ed1aa0994e328206e6d5aeacc4dc
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393868B2

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