Benzocaine → Ethyl 4-(piperidin-1-yl)benzoate

HRID 747678

반응식

HRID 747678 반응식
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]Br.C(N(C(C)C)CC)(C)C>C1C=CC=CC=1.O>[N:1]1([C:2]2[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

참가 물질

6

반응물 3

HCID 2337BenzocaineHCID 81001,5-DibromopentaneHCID 81531Diisopropylethylamine

생성물 1

HCID 13813852Ethyl 4-(piperidin-1-yl)benzoate

시약·촉매·용매 2

HCID 241Benzene용매HCID 962Water용매

실험 절차

2.16 g (13.1 mmol) of ethyl 4-aminobenzoate was dissolved in 20 ml of benzene. 2.97 g (13.0 mmol) of 1,5-dibromopentane and 4.53 ml (26.0 mmol) of diisopropylethylamine were added to the solution, and they were heated under reflux for 48 hours. The reaction liquid was diluted with water. After the extraction with ethyl acetate, the organic layer was washed with water and then with saturated aqueous NaCl solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the crude title compound.

후처리

  1. temperaturewere heated
  2. temperatureunder reflux for 48 hours
  3. customThe reaction liquid
  4. extractionAfter the extraction with ethyl acetate
  5. washthe organic layer was washed with water
  6. dry with materialwith saturated aqueous NaCl solution, and dried over anhydrous magnesium sulfate
  7. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-ad3bbc83df2049d0ab063b65240d4ace
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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