Hydrochloric Acid → 1-Amino-3-(cholestan-3-yloxy)-propane

HRID 74861

반응식

HRID 74861 반응식
[CH3:1][CH:2]([CH2:4][CH2:5][CH2:6][C@H:7]([C@@H:9]1[C@:26]2([CH3:27])[C@H:12]([C@H:13]3[C@H:23]([CH2:24][CH2:25]2)[C@:21]2([CH3:22])[CH:16]([CH2:17][CH:18]([O:28][CH2:29][CH2:30][C:31]#[N:32])[CH2:19][CH2:20]2)[CH2:15][CH2:14]3)[CH2:11][CH2:10]1)[CH3:8])[CH3:3].C(Cl)(Cl)Cl.CCO.Cl>C1(C)C=CC=CC=1.O.[Pt]=O>[NH2:32][CH2:31][CH2:30][CH2:29][O:28][CH:18]1[CH2:19][CH2:20][C@@:21]2([CH3:22])[CH:16]([CH2:15][CH2:14][C@@H:13]3[C@@H:23]2[CH2:24][CH2:25][C@@:26]2([CH3:27])[C@H:12]3[CH2:11][CH2:10][C@@H:9]2[C@H:7]([CH3:8])[CH2:6][CH2:5][CH2:4][CH:2]([CH3:1])[CH3:3])[CH2:17]1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6212ChloroformHCID 674348303-(Cholestan-3-yloxy)propanenitrile

생성물 1

HCID 674336311-Amino-3-(cholestan-3-yloxy)-propane

시약·촉매·용매 2

HCID 86587499Platinum oxide monohydrate촉매HCID 1140Toluene용매

실험 절차

3-(Cholestan-3-yloxy)propanenitrile 135 (442 mg, 1 mmol) was taken up in a mixture of toluene (1 mL), chloroform (1.5 mL), EtOH (1 mL) and conc. HCl (200 μL). Platinum oxide hydrate (46 mg) was added. The mixture was stirred under hydrogen (80 psi) at room temperature for 48 hours. The solvent was evaporated and the residue taken up with DCM (40 mL) and NaHCO3 (sat.) (40 mL). The organic phase was separated and washed with NaHCO3 (sat.) (30 mL), followed by brine (20 mL), before being dried (Na2SO4) and the solvent evaporated to yield the white foam product which was reacted on without further purification or characterization.

후처리

  1. customThe solvent was evaporated
  2. customThe organic phase was separated
  3. washwashed with NaHCO3 (sat.) (30 mL)
  4. dry with materialbefore being dried (Na2SO4)
  5. customthe solvent evaporated
  6. customto yield the white foam product which
  7. customwas reacted on without further purification or characterization

출처 및 근거

ORD 기록
ord-8d1a18749b7445aa82209e3c4e390308
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828952B2

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