Sodium hydride → HCID 66886112, 화합물

HRID 750888

반응식

HRID 750888 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]=[C:12]([CH3:14])[NH:11][N:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.[H-].[Na+].[C:17]([O:21][C:22](=[O:30])[NH:23][C:24]([CH3:29])([CH3:28])[CH2:25][CH2:26]Cl)([CH3:20])([CH3:19])[CH3:18]>CN1C(=O)N(C)CCC1.[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[F:8][C:6]1[CH:5]=[C:4]([C:9]2[N:13]=[C:12]([CH3:14])[N:11]([CH2:26][CH2:25][C:24]([NH:23][C:22](=[O:30])[O:21][C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:29])[CH3:28])[N:10]=2)[CH:3]=[C:2]([F:1])[CH:7]=1

참가 물질

6

반응물 3

HCID 24758Sodium hydrideHCID 431668063-(3,5-Difluoro-phenyl)-5-methyl-[1,2,4]triazoleHCID 57429079tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate

생성물 1

HCID 66886112HCID 66886112, 화합물

시약·촉매·용매 2

HCID 67553Tetrabutylammonium Iodide촉매HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-용매

실험 절차

3.74 g (19 mmol) 3-(3,5-difluoro-phenyl)-5-methyl-[1,2,4]triazole in 25 mL DMPU are reacted with 0.92 g (23 mmol, 60%) sodium hydride, 6.37 g (29 mmol) tert-butyl(3-chloro-1,1-dimethyl-propyl)-carbamate and 1.27 g (3.5 mmol) tetrabutylammonium iodide analogously to Example 1c). Oil.

출처 및 근거

ORD 기록
ord-c83cb912310d4d90aad5d3b1f80e21bc
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405232B2

연결된 노트

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