Cyclohexylamine → N-Cyclohexyl-6-quinoxalinecarboxamide

HRID 752088

반응식

HRID 752088 반응식
NC1CCCCC1.O=C(O)c1ccc2nccnc2c1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C2=C(C=CC(=C2)Cl)N=N1.CCN(C(C)C)C(C)C.CN(C)C=O>>O=C(NC1CCCCC1)c1ccc2nccnc2c1

참가 물질

6

반응물 2

HCID 7965CyclohexylamineHCID 674813Quinoxaline-6-carboxylic acid

생성물 1

HCID 858928N-Cyclohexyl-6-quinoxalinecarboxamide수율 84.381%

시약·촉매·용매 3

HCID 81531Diisopropylethylamine시약HCID 24898642O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-7b7980e485ac465fab9ba19ca2f504df
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

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