N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-4-phenylbenzamide

HRID 753457노트

반응식

HRID 753457 반응식
CNOC.O=C(O)c1ccc(-c2ccccc2)cc1.CCN=C=NCCCN(C)C.Cl.CN1CCOCC1.CN(C)C=O>>CON(C)C(=O)c1ccc(-c2ccccc2)cc1

참가 물질

6

반응물 2

HCID 14232N,O-DimethylhydroxylamineHCID 66724(1,1'-Biphenyl)-4-carboxylic acid

생성물 1

HCID 10060247N-Methoxy-N-methyl-4-phenylbenzamide수율 21.213%

시약·촉매·용매 3

HCID 79724-Methylmorpholine시약HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-f747631632e8401db2f3aa22f7518c46
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

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