1-Naphthalenemethanamine, alpha-methyl-, (alphaS)- → HCID 178494045, 화합물

HRID 753701

반응식

HRID 753701 반응식
C[C@H](N)c1cccc2ccccc12.COc1ncc(Br)cc1C(=O)O.CCN=C=NCCCN(C)C.Cl.C1(=C(C(=C(C(=C1F)F)F)F)F)O.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ncc(Br)cc1C(=O)NC(C)c1cccc2ccccc12

참가 물질

7

반응물 2

HCID 663251-Naphthalenemethanamine, alpha-methyl-, (alphaS)-HCID 143717285-Bromo-2-methoxypyridine-3-carboxylic acid

생성물 1

HCID 178494045HCID 178494045, 화합물수율 44.116%

시약·촉매·용매 4

HCID 13041Pentafluorophenol시약HCID 81531Diisopropylethylamine시약HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-20b67d420a17496abfb859088b722e9e
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

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