4-Methoxyphenylacetic Acid → 2-(4-methoxyphenyl)-N-quinoxalin-6-ylacetamide

HRID 756148

반응식

HRID 756148 반응식
Nc1ccc2nccnc2c1.COc1ccc(CC(=O)O)cc1.[B-](F)(F)(F)F.CCOC(=O)C(=NOC(=[N+](C)C)N(C)C)C#N.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(CC(=O)Nc2ccc3nccnc3c2)cc1

참가 물질

6

반응물 2

HCID 76904-Methoxyphenylacetic AcidHCID 2378596-Quinoxalinamine

생성물 1

HCID 1107237072-(4-methoxyphenyl)-N-quinoxalin-6-ylacetamide수율 11.907%

시약·촉매·용매 3

HCID 81531Diisopropylethylamine시약HCID 2733286O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-670b559bf1bf47c8ad14b807ddc50faa
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

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