Ethanol → 2-Oxopyrrolidine-3-carboxylic acid

HRID 76181

반응식

HRID 76181 반응식
C(OC([N:6]1[CH2:10][CH2:9][CH2:8][C:7]1=[O:11])=O)C.[OH-:12].[Na+].C[CH2:15][OH:16]>>[O:11]=[C:7]1[CH:8]([C:15]([OH:16])=[O:12])[CH2:9][CH2:10][NH:6]1

참가 물질

4

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 234959Ethyl 2-oxopyrrolidine-1-carboxylate

생성물 1

HCID 134743702-Oxopyrrolidine-3-carboxylic acid

실험 절차

To 0.50 g (3.18 mmol) 2-oxo-pyrollidine-carboxylic acid ethyl ester in 10 mL EtOH are added 5 mL aq. NaOH (1M) solution. The reaction mixture is stirred at r.t. for 3 h. The EtOH is removed in vacuo and the residue is diluted with water and acidified with aq. HCl (2M) solution. The resulting precipitate is filtered and dried.

후처리

  1. customThe EtOH is removed in vacuo
  2. additionthe residue is diluted with water
  3. filtrationThe resulting precipitate is filtered
  4. customdried

출처 및 근거

ORD 기록
ord-eb7275050f334e848da4cf494465570b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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