Sodium Carbonate → 3-bromo-1-ethyl-quinoxalin-2(1H)-one
반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5](=O)[C:4]1=[O:14])[CH3:2].P(Br)(Br)([Br:17])=O.C(=O)([O-])[O-].[Na+].[Na+]>ClC(Cl)C>[Br:17][C:5]1[C:4](=[O:14])[N:3]([CH2:1][CH3:2])[C:12]2[C:7]([N:6]=1)=[CH:8][CH:9]=[CH:10][CH:11]=2참가 물질
5
실험 절차
To 2 g (10.5 mM) of 1-ethyl-1,4-dihydroquinoxaline-2,3-dione in 20 ml of dichloroethane were added dropwise 3.16 g (11.0 mM) of POBr3. The reaction mixture was refluxed under stirring for 2 h and then treated with ice cold and an aqueous sodium carbonate solution. The mixture was filtered and the filtrate was extracted with dichloromethane, dried over anhydrous sodium sulfate and concentrated to give 1.4 g of 3-bromo-1-ethyl-quinoxalin-2(1H)-one as a yellow solid. Yield: 53%.
후처리
- temperatureThe reaction mixture was refluxed
- additiontreated with ice cold
- filtrationThe mixture was filtered
- extractionthe filtrate was extracted with dichloromethane
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-cffd98ecd0f34ad1a0c86bed52615424
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08835634B2
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