3-Aminophenol → N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine
반응식
[OH:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:12](F)=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.Cl[C:25]1N=C(Cl)C(C)=CN=1.OC1C=C(C=CC=1)N>>[OH:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:12]([CH3:25])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
In a manner analogous to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloro-5-methylpyrimidine with 3-hydroxyaniline gave N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine. LCMS: ret. time: 16.76 min.; purity: 100%, MS (m/e): 309 (MH+).
출처 및 근거
- ORD 기록
- ord-8c6534cf8c2b4b498f754b21096ee7d9
- 출처 데이터셋
- uspto-grants-2014_09
- DOI