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Hydrochloric Acid → (S)-3-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

HRID 76802
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인쇄 미리보기

반응식

HRID 76802 반응식
C[O:2][C:3](=[O:36])[C@@H:4]([NH:17][S:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][C:28]2=[O:33])[C:22]=1[CH2:34][CH3:35])(=[O:20])=[O:19])[CH2:5][C:6]1[CH:10]=[C:9]([C:11]2[S:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[O:8][N:7]=1.[Li+].[OH-].Cl>C1COCC1.CO.O>[Cl:16][C:13]1[S:12][C:11]([C:9]2[O:8][N:7]=[C:6]([CH2:5][C@H:4]([NH:17][S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][C:28]4=[O:33])[C:22]=3[CH2:34][CH3:35])(=[O:20])=[O:19])[C:3]([OH:36])=[O:2])[CH:10]=2)=[CH:15][CH:14]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 66911103(S)-3-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid methyl ester

생성물 1

HCID 66911167(S)-3-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

시약·촉매·용매 3

HCID 887
Methanol
용매
HCID 962Water용매
HCID 8028Tetrahydrofuran용매

실험 절차

Intermediate 7 (1.5 g, 2.71 mmol) in THF (15 ml), MeOH (5 ml) and water (5 ml) was treated with LiOH (194 mg, 8.12 mmol) and stirred at RT overnight. The mixture was acidified with HCl and extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried with MgSO4, filtered and evaporated to dryness. The crude product (1.3 g) was used without further purification in the next step.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with water and brine
  3. dry with materialdried with MgSO4
  4. filtrationfiltered
  5. customevaporated to dryness
  6. customThe crude product (1.3 g) was used without further purification in the next step

출처 및 근거

ORD 기록
ord-bbeba29e22a04a3a98f40a2768309dc9
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08835653B2

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