Hydroxyamine hydrochloride → 2-Amino-pyridine-3-carbaldehyde oxime

HRID 77856

반응식

HRID 77856 반응식
[NH2:1][C:2]1[C:7]([CH:8]=O)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl.[NH2:11][OH:12]>N1C=CC=CC=1>[NH2:1][C:2]1[C:7]([CH:8]=[N:11][OH:12])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 7376333-Pyridinecarboxaldehyde, 2-amino-

생성물 1

HCID 533951902-Amino-pyridine-3-carbaldehyde oxime수율 85%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 2-amino-3-formylpyridine (1.00 g, 8.19 mmol) in pyridine (20 mL) was added hydroxylamine hydrochloride (854 mg, 12.3 mmol) at room temperature, which was stirred for 1 hour and 40 minutes at room temperature. The reaction solution was partitioned into water and ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate: methanol=10:1) to obtain the title compound (951 mg, 85%).

후처리

  1. customThe reaction solution was partitioned into water and ethyl acetate
  2. washThe organic layer was washed with water and saturated aqueous sodium chloride
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under a reduced pressure
  5. customThe residue was purified by NH silica gel column chromatography (ethyl acetate: methanol=10:1)

출처 및 근거

ORD 기록
ord-7d48683d5bce425bb760a1b931bcd747
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841327B2

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