Acetic Acid → trans-4-Bromo-beta-nitrostyrene

HRID 78241

반응식

HRID 78241 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[N+:10]([CH3:13])([O-:12])=[O:11].C([O-])(=O)C.[NH4+].C(O)(=O)C>O>[Br:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[CH:13]/[N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 6375NitromethaneHCID 707414-BromobenzaldehydeHCID 517165Ammonium Acetate

생성물 1

HCID 688204trans-4-Bromo-beta-nitrostyrene수율 83.8%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4-bromobenzaldehyde (16.8 g, 91 mmol), nitromethane (24.6 mL, 455 mmol), ammonium acetate (14 g, 182 mmol), and acetic acid (160 mL) was stirred for 4 hours at 100° C. This mixture was cooled to room temperature and poured into water. The precipitate thus produced was collected, washed with water, and dried under a reduced pressure to obtain the title compound (17.4 g). The title compound was used in the following reaction without any further purification.

후처리

  1. temperatureThis mixture was cooled to room temperature
  2. customThe precipitate thus produced
  3. customwas collected
  4. washwashed with water
  5. customdried under a reduced pressure

출처 및 근거

ORD 기록
ord-047d50064f2148ab898bc3dc70987e87
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841327B2

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