Hydrochloric Acid → 4-bromo-3-(trifluoromethyl)aniline HCl salt

HRID 78324

반응식

HRID 78324 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[ClH:13]>CCOCC>[ClH:13].[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 678524-Bromo-3-(trifluoromethyl)aniline

생성물 1

HCID 667457074-bromo-3-(trifluoromethyl)aniline HCl salt수율 98%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 4-bromo-3-(trifluoromethyl)aniline (64 g, 267 mmol) in Et2O (500 mL) was added an HCl solution (1 M in Et2O; 300 mL) dropwise and the resulting mixture was stirred at room temp. for 16 h. The resulting pink-white precipitate was removed by filtration and washed with Et2O (50 mL) and to afford 4-bromo-3-(trifluoromethyl)aniline HCl salt (73 g, 98%).

후처리

  1. customThe resulting pink-white precipitate was removed by filtration
  2. washwashed with Et2O (50 mL)

출처 및 근거

ORD 기록
ord-e7dd352353774123b85fa211e6af2f99
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841330B2

연결된 노트

불러오는 중…