Hydrochloric Acid → 4-bromo-3-(trifluoromethyl)aniline HCl salt
반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[ClH:13]>CCOCC>[ClH:13].[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]참가 물질
4
실험 절차
To a solution of 4-bromo-3-(trifluoromethyl)aniline (64 g, 267 mmol) in Et2O (500 mL) was added an HCl solution (1 M in Et2O; 300 mL) dropwise and the resulting mixture was stirred at room temp. for 16 h. The resulting pink-white precipitate was removed by filtration and washed with Et2O (50 mL) and to afford 4-bromo-3-(trifluoromethyl)aniline HCl salt (73 g, 98%).
후처리
- customThe resulting pink-white precipitate was removed by filtration
- washwashed with Et2O (50 mL)
출처 및 근거
- ORD 기록
- ord-e7dd352353774123b85fa211e6af2f99
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08841330B2
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