Propargyl bromide → 4,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide

HRID 78534

반응식

HRID 78534 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[C:10]#[CH:11]>C1(C)C=CC=CC=1.C(OCC)C>[BrH:12].[CH3:1][C:2]1[N:3]([CH2:11][C:10]#[CH:9])[C:4](=[NH:8])[S:5][C:6]=1[CH3:7]

참가 물질

5

반응물 2

HCID 7842Propargyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

생성물 1

HCID 866408574,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide수율 72.6%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 3283Diethyl Ether용매

반응 조건

온도
85 °C

실험 절차

To a solution of 4,5-dimethylthiazol-2-amine (2.5 g, 19.5 mmol) in 10 mL toluene was added propargyl bromide (2.78 g, 23.4 mmol). The reaction was heated at 85° C. for 12 h then cooled. The crude material was diluted with diethyl ether and the solid was collected via filtration to give 3.5 g of the title compound which was used without further purification. m/z 167.1 (M+H)+.

후처리

  1. temperaturethen cooled
  2. filtrationthe solid was collected via filtration

출처 및 근거

ORD 기록
ord-b6f5b5843ebb4d588a2e5b6422eff13e
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841334B2

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