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N-bromobutanimide → Methyl 3-Amino-6-bromopyrazine-2-carboxylate

HRID 78555
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인쇄 미리보기

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HRID 78555 반응식
[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[Br:12]N1C(=O)CCC1=O>CC#N>[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][C:5]([Br:12])=[CH:6][N:7]=1
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참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 72669Methyl 3-aminopyrazinecarboxylate

생성물 1

HCID 227251Methyl 3-Amino-6-bromopyrazine-2-carboxylate수율 92.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of methyl 3-aminopyrazine-2-carboxylate (8.35 g, 54.53 mmol) and N-bromo-succinimide (9.705 g, 54.53 mmol) was stirred in MeCN (100 mL) at room temp overnight. The resultant precipitate was filtered, washed with MeCN and dried to give the desired product as a yellow solid (11.68 g, 92% Yield)

후처리

  1. filtrationThe resultant precipitate was filtered
  2. washwashed with MeCN
  3. customdried

출처 및 근거

ORD 기록
ord-9c45557af7b8499583d6e81ed74ae82b
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841308B2

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