Hydrochloric Acid → 3-Amino-6-bromopyrazine-2-carboxylic acid

HRID 78556

반응식

HRID 78556 반응식
[NH2:1][C:2]1[C:3]([C:9]([O:11]C)=[O:10])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1.[OH-].[Li+].Cl>CO.O>[NH2:1][C:2]1[C:3]([C:9]([OH:11])=[O:10])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 227251Methyl 3-Amino-6-bromopyrazine-2-carboxylate

생성물 1

HCID 185216003-Amino-6-bromopyrazine-2-carboxylic acid수율 99%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

A mixture of methyl 3-amino-6-bromo-pyrazine-2-carboxylate (5.11 g, 22.02 mmol) and lithium hydroxide (2.637 g, 110.1 mmol) in MeOH (20 mL) and H2O (20 mL) was heated to 90° C. for 2 hours. The reaction mixture was allowed to cool and neutralised with HCl and the resultant precipitate collected by filtration. Taken on to the next step without further purification (4.80 g, 99% Yield).

후처리

  1. temperatureto cool
  2. filtrationthe resultant precipitate collected by filtration
  3. customTaken on to the next step without further purification (4.80 g, 99% Yield)

출처 및 근거

ORD 기록
ord-77359acbc1aa4950849dc47286518239
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841308B2

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