Hydrochloric Acid → 1-(3-Fluoro-4-methoxyphenyl)hexan-1-one

HRID 7887

반응식

HRID 7887 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH3:13].[C:14](Cl)(=[O:20])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].Cl>>[F:5][C:6]1[CH:11]=[C:10]([C:14](=[O:20])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH:9]=[CH:8][C:7]=1[O:12][CH3:13]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 67340Hexanoyl chlorideHCID 675762-FluoroanisoleHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 219909101-(3-Fluoro-4-methoxyphenyl)hexan-1-one수율 90.4%

실험 절차

Aluminum chloride (6.5 g, 48.8 mmol) was added to a stirred mixture of 1-fluoro-2-methoxybenzene (5.0 mL, 44.4 mmol) and hexanoyl chloride (7.5 mL, 53.3 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 45 minutes and then partitioned between EtOAc (100 mL) and water (100 mL). The EtOAc layer was washed with water (100 mL), aqueous K2CO3 (100 mL) and brine (50 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-fluoro-4-methoxyphenyl)-1-hexanone (9 g) as a solid.

후처리

  1. temperatureThe mixture warmed
  2. custompartitioned between EtOAc (100 mL) and water (100 mL)
  3. washThe EtOAc layer was washed with water (100 mL), aqueous K2CO3 (100 mL) and brine (50 mL)
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-964e1b3c9e4a4ee4925791c3c6f268ce
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087599B2

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