Carbon tetrabromide → 2-(Bromomethyl)-6-methylpyridine
반응식
[CH3:1][C:2]1[N:7]=[C:6]([CH2:8]O)[CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:30]>ClCCl>[Br:30][CH2:8][C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=1참가 물질
5
실험 절차
To an ice cooled a solution of (6-methylpyridin-2-yl)methanol (400 mg, 3.25 mmol) in dichloromethane (16 mL) under an atmosphere of dry nitrogen was added triphenylphosphine (1278 mg, 4.87 mmol) and carbon tetrabromide (1616 mg, 4.87 mmol). The mixture was stirred for 1 hour. The solvent was removed under reduced pressure and the residue was purified by chromatography on silica, eluting with 2-4% methanol in dichloromethane to give 2-(bromomethyl)-6-methylpyridine as an oil (402 mg).
후처리
- customThe solvent was removed under reduced pressure
- customthe residue was purified by chromatography on silica
- washeluting with 2-4% methanol in dichloromethane
출처 및 근거
- ORD 기록
- ord-d5b7f4e6014b4c3e92fe9055a43e9c05
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08841455B2
반응 노트
불러오는 중…